Gentiana lutea L. Activity

Ponticelli, Maria, Lela, Ludovica, Moles, Mariapia, Mangieri, Claudia, Bisaccia, Donatella, Faraone, Immacolata, Falabella, Roberto & Milella, Luigi, 2023, The healing bitterness of Gentiana lutea L., phytochemistry and biological activities: A systematic review, Phytochemistry (113518) 206, pp. 1-27 : 18

3.8. Gentiana lutea L. Activity again atopic dermatitis and psoriasis

The stratum corneum is formed principally by differentiated keratinocytes surrounded by an extracellular lipid bilayer. Lipids forming this bilayer are secreted from lipid droplets, consisting of intracellular organelles specialized in lipids storage, assemblage, and supply ( Feingold et al., 2007). In keratinocytes, lipid droplets are generated during their differentiation, reaching the maximum number in the stratum granulosum when there is the highest extracellular calcium level ( Feingold, 2009). Several lipids contribute to optimizing epidermal barrier function, and ceramides are particularly important among these. Indeed, reducing ceramide levels is involved in several skin disorders, such as atopic dermatitis and psoriasis, which are also characterized by inflammation and dysregulation in keratinocytes synthesis. Active principles from G. lutea have been demonstrated to improve skin disorders.