Bletilla formosana
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publication ID |
https://doi.org/ 10.1016/j.phytochem.2021.113059 |
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persistent identifier |
https://treatment.plazi.org/id/917BE622-FFB9-FFB2-4B69-FC6FFBB1E7C0 |
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treatment provided by |
Felipe |
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scientific name |
Bletilla formosana |
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2.5. Anti-melanogenic effects and toxicity of B. striata , B. ochracea , and
B. formosana View in CoL View at ENA in zebrafish embryos
In addition to estimating the potential of B. striata , B. ochracea , and B. formosana for further medical application as depigmenting agents, we further evaluated its anti-pigmentation ability through in vivo zebrafish model, and compared their depigmenting efficacy with winona. As seen from Table 3, there was no obvious histological abnormality when the concentrations of B. striata , B. ochracea , and B. formosana were below 62.5 μg/mL, respectively. Therefore, the MTC of anti-melanogenic experiment was determined as 62.5 μg/mL.
After the incubation of zebrafish embryos from 6 hpf to 54 hpf, B. striata , B. ochracea , and B. formosana exhibited an obvious pigmentation inhibitory activity at concentrations of 31.25 μg/mL compared to control group, with the pigmentation level markedly decreases about 19%, 14%, and 20%, respectively ( Fig. 7 View Fig , and Table 4). There was no significant difference between B. striata and B. formosana treatment groups. However, the average anti-melanogenic effect in B. ochracea was the lowest among them(see Fig. 8 View Fig ). The results were consistent with the clustering results of characteristic components of B. striata , B. ochracea , and B. formosana . The above results revealed quite similar depigmenting potency and toxicity profile of B. striata , B. ochracea , and B. formosana at the doses of 15.625–250 μg/mL.
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